Semaglutide
Taking smaller doses more frequently (once daily) can reduce the different between trough and peak drug levels, leading to a smoother titration and a smoother steady state concentration as compared to once weekly dosing.1
A recent in vitro study demonstrated the ability of our compounding base to deliver semaglutide into and through human gingival and oral tissues.2
“Evaluation of the Absorption of a Sublingual Semaglutide Compounded Formulation (SubMagna™ SL HMW) using the EpiGingival™ and EpiOral™ In Vitro Tissue Models” Technical Report. PCCA Science 2024
GLP-1 Receptor Agonists
The usage of GLP-1 receptor agonists has grown worldwide. This class includes several different injectable medications, as well as an orally delivered drug. Many patients would prefer to avoid injections if possible, and there is an extremely low absorption of oral tablets (less than 1% per the labeling for RYBELSUS®). For these and other potential valid reasons, prescribers and patients may prefer a sublingual compounded formulation of semaglutide.
What Is Sublingual Semaglutide And How Is It Different?
Sublingual (SL) Semaglutide is a compounded suspension of semaglutide that is designed to be administered under the tongue (sublingually). Our patent-pending formulation utilizes a special base designed to carry large molecules (high molecular weight substances), such as semaglutide, through the oral mucosal membrane. This self-emulsifying base has permeation-enhancing and unique muco-adhesive properties that help drive molecules into mucosal tissue.
What Is The Dosage And How Is It Supplied?
Recommended starting dose: Compounded Semaglutide Suspension 1mg/mL QTY: 30mL
Place 0.25mL under the tongue for 90 seconds then swallow once daily. May increase to 0.5mL daily or as directed by your provider. Based on response, may increase to 1mL daily as directed by your provider.
Providers:
An important consideration when titrating the dose is that semaglutide has a half-life of approximately 7 days and will usually take 4-5 weeks to reach steady state drug concentrations. Also, since the doses are daily instead of weekly, patients may experience a smoother titration and maintain a more consistent steady state concentration.
Patients:
If you are starting semaglutide for the first time, you may be instructed to begin with a titration as directed by your provider. This means that you will start with a smaller dose and increase over time. Titrating this medication can help reduce gastrointestinal side effects and nausea. After a dosage increase it can take up to 4-5 weeks to reach maximum medication levels for that dose.
The medication comes in an amber bottle with a 1ml dropper for easy under-the-tongue administration. It should be stored at room temperature and shaken before use. The dose determined by your doctor should be applied under your tongue for at least 90 seconds but up to 5 minutes and then swallowed. Avoid eating or drinking anything for at least 30 minutes after administration.
How Much Does it Cost?
30mL of 1mg/mL suspension is $248.90
How Do I Get (Or Prescribe) Sublingual Semaglutide?
Providers:
- We accept faxed Rxs to 406-869-0134 (see fax form)
- Phoned Rxs to 406-259-1515
- E-prescribed Rxs to Juro’s Pharmacy by
- Selecting Rybelsus® 14mg tabs, typing the following into the sig field: compounded semaglutide 1mg/mL, 0.25mL SL daily…(etc), qty: 30mL
Patients:
Sublingual Semaglutide is available with a valid prescription from your healthcare provider. Once we have a prescription we will reach out to you with more details.
We created a prescription order form that you may print and bring to your appointment to discuss this medication with your provider. (The second page of this document will provide more information for your provider) Our Fax # is 406-869-0134
